| 肺炎衣原体与冠心病关系的研究 |
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| 引用本文： | 李文化,张雪雨,程铮,李新军,宋彦恩. 肺炎衣原体与冠心病关系的研究[J]. 陕西医学杂志, 2008, 37(1): 62-64 |
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| 作者姓名： | 李文化 张雪雨 程铮 李新军 宋彦恩 |
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| 作者单位： | 河北北方学院第二附属医院内四病区,张家口,075100 |
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| 基金项目： | 河北省科技厅指导项目(No 002761107) |
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| 摘 要： | 目的:探讨肺炎衣原体(TWAR)与冠状动脉粥样硬化心脏病(CHD)之间的关系。方法:采用多聚合酶链反应(PCR)技术对200例冠心病和180例非冠心病患者进行全血标本肺炎衣原体DNA检测。结果:冠心病组肺炎衣原体DNA阳性率为57.5%,对照组为21.1%,两组有显著性差异(P<0.01);另外,在冠心病组,肺炎衣原体DNA阳性率:男性显著高于女性(P<0.01);吸烟患者显著高于非吸烟患者(P<0.01);急性心梗较其他类型冠心病相比有显著性差异(P<0.01)。结论:肺炎衣原体感染与冠心病存在密切关系,可能是冠心病发生、发展的因素之一。
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| 关 键 词： | 冠状动脉疾病/病因学 冠状动脉疾病/血液 衣原体,肺炎/血液 聚合酶链反应 |
| 收稿时间： | 2007-05-28 |
| 修稿时间： | 2007-05-28 |
Relationship between chlamydia pneumoniae and coronary atherosclerotic heart disease |
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| Li Wenhua, Zhang Xueyu, Cheng Zheng et al. Relationship between chlamydia pneumoniae and coronary atherosclerotic heart disease[J]. Shaanxi Medical Journal, 2008, 37(1): 62-64 |
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| Authors: | Li Wenhua Zhang Xueyu Cheng Zheng et al |
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| Affiliation: | Zhangjiakou 075100 |
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| Abstract: | Objective: To investigate the relationship between chlamydia pneumoniae(TWAR) and coronary atherosclerotic heart disease(CHD) . Methods: By means of polymerase chain reaction(PCR), TWAR nucleic acid were detected in 200 patients with CHD and 180 control subjects.Results:The positivity rate of TWAR-DNA was 57.5%(115/200) in the patient group and 21.1%(38/180) in the control group, showing obvious difference between the two groups(P <0.01). In addition, the positivity rate of TWAR-DNA was 64.8%, 71.6%, 73.2% in male , smoking or AMI patients with CHD and 26.3%, 17.3%, 51.3% in the control patients with CHD, respectively, which shows significant difference (P<0.01, P <0.01, P <0.01). Conclusion:TWAR infection is closely connected with CHD, and may be one of the risk factors in CHD mechanisms. |
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| Keywords: | Coronary disease/etiology Coronary disease/blood Chlamydophila pneumoniae/blood Polymerase chain reaction |
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