| GDP方案治疗复发和难治性弥漫性大B细胞淋巴瘤的疗效分析 |
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| 引用本文： | 刘永钟,梁淑仪,彭杰文,梁汉霖,殷兆锋,贺景焕.GDP方案治疗复发和难治性弥漫性大B细胞淋巴瘤的疗效分析[J].中国肿瘤临床与康复,2011(6):519-522. |
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| 作者姓名： | 刘永钟 梁淑仪 彭杰文 梁汉霖 殷兆锋 贺景焕 |
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| 作者单位： | 中山市人民医院化疗科;中山市人民医院神经内科; |
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| 摘 要： | 目的探讨GDP方案(吉西他滨、顺铂、氟美松)治疗复发和难治性弥漫性大B细胞淋巴瘤(DLBCL)的近期疗效和毒副反应。方法 26例复发和难治性弥漫性大B细胞淋巴瘤采用GDP方案治疗:吉西他滨1000 mg/m2静脉滴注,第1、8天;顺铂25 mg/m2静脉滴注,第1～3天;氟美松40mg/d口服,第1～4天,21 d为1个周期。观察疗效和毒副反应,并随访疾病进展情况。结果 26例均能评价疗效,复发组18例总缓解率(RR)为66.7%(12/18),中位肿瘤进展时间(TTP)为7.3个月(4.5～11.2个月),难治组8例总缓解率(RR)为62.5%(5/8),中位肿瘤进展时间(TTP)为6.5个月(2.9～10.1个月),经统计学检验两组间RR及中位TTP差异均无统计学意义;且毒副反应程度较轻,毒副反应主要为白细胞和血小板减少,但均为可逆,未出现因化疗毒性而死亡患者。结论 GDP方案是治疗复发和难治性弥漫性大B细胞淋巴瘤安全有效的可行解救方案,缓解率高,化疗耐受性好。
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| 关 键 词： | 弥漫性大B细胞淋巴瘤 化学疗法 GDP方案 |
GDP regimen in Treatment of relapsed and refractory diffuse large B-cell lymphoma and its efficacy |
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| LIU Yong-zhong,LIANG Shu-yi,PENG Jie-wen,et al.GDP regimen in Treatment of relapsed and refractory diffuse large B-cell lymphoma and its efficacy[J].Chinese Journal of Clinical Oncology and Rehabilitation,2011(6):519-522. |
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| Authors: | LIU Yong-zhong LIANG Shu-yi PENG Jie-wen |
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| Institution: | LIU Yong-zhong1,LIANG Shu-yi2,PENG Jie-wen1,et al |
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| Abstract: | Objective To evaluate the short-term effect and side effects of GDP regimen treating the patients with relapsed and refractory diffuse large B-cell lymphoma(DLBCL).Method Twenty-six patients with relapsed and refractory DLBCL were treated with GDP regimen,GDP regimen:gemcitabine(GEM) 1 000 mg/m2 IVD on day 1 and 8;cisplatine(DDP) 25mg/m2 IVD on day 1 to 3;dexamethasone(DXM) 40 mg/d P.O.on day 1 to 4;Treatment was repeated Every 3 weeks.Result The response rate(RR)of relapsed group was 66.7%(12/18),the media... |
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| Keywords: | DLBCL Chemotherapy GDP regimen |
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