| 牛磺酸对睡眠剥夺大鼠学习记忆的影响 |
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| 引用本文： | 魏林郁,王宝英,李炳. 牛磺酸对睡眠剥夺大鼠学习记忆的影响[J]. 现代医药卫生, 2008, 24(19): 2866-2868 |
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| 作者姓名： | 魏林郁 王宝英 李炳 |
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| 作者单位： | 新乡医学院生理学教研室 |
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| 基金项目： | 河南省卫生厅医学科技攻关计划项目(项目编号：200686)河南省卫生厅医学科技攻关计划项目(项目编号：07s049) |
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| 摘 要： | 目的:研究牛磺酸(taurine,Tau)对睡眠剥夺(sleep deprivation,SD)大鼠学习记忆的影响。方法:用小平台水环境(flower pot)法建立SD大鼠模型,SD72h后用Morris水迷宫测定大鼠学习记忆能力。结果:SD72h后逃避潜伏期实验组显著低于对照组,穿环系数实验组显著高于对照组,且以中剂量组的效果最好。结论:牛磺酸对SD所致的大鼠学习记忆障碍有明显的改善作用。
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| 关 键 词： | 牛磺酸 睡眠剥夺 学习记忆 |
Effect of taurine on learning and memory in rats after sleep deprivation |
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| WEI Lin-yu,WANG Bao-ying,LI Bing. Effect of taurine on learning and memory in rats after sleep deprivation[J]. JOURNAL OF MODERN MEDICINE & HEALTH, 2008, 24(19): 2866-2868 |
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| Authors: | WEI Lin-yu WANG Bao-ying LI Bing |
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| Abstract: | Objective:To study the effect of taurine on learning and memory in rats after sleep deprivation. Methods:Sleep deprivation was induced in male Sprague-Dawley rats by using "Flower Pot" technique. Learning and memory ability in rats were measured by Morris maze after 72 hours sleep deprivation.Results:Compared with control group,the mean escap period of experimental groups decreased significantly after 72 hours sleep deprivation, the crossing annulus coefficie increased markedly,especially in the medium dose group. Conclusion:Taurine can obviously improve the learning and memory dysmnesia in rats induced by sleep deprivation. |
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| Keywords: | Taurine Sleep deprivation(SD) Learning and memory |
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