Survivin在胆管癌表达与预后的关系

目的 探讨胆管癌患者中Survivin的表达在提示预后中的作用.方法 48例手术切除的胆管癌标本,应用免疫组织化学技术(SP法)检测Survivin基因在48例胆管癌中的表达.Survivin的表达分别描述为阴性或弱阳性和强阳性.结果 Survivin在胞质和细胞核表达例数分别为26例和22例患者.细胞质中强阳性表达为12例,而细胞核强阳性表达的则有8例.细胞核强阳性表达的患者平均存活期为10个月,明显低于弱阳性表达的患者(19个月,P＜0.05).Cox比例风险率模型的多因素分析方法 证实存在2个独立的预后因素:Survivin细胞核表达(P＜0.05)和远处转移(P＜0.05).结论 胆管癌中Survivin的细胞核表达可提示较差的预后.

Nuclear surviving expression predicts poor prognosis in cholangiocarcinonm

Objective To study the prognostic role of survivin expressed in cholangiocarcinoma. Methods Forty-eight cases of cholangiocarcinoma were studied. Immunohistochemistry was performed u-sing a monoclonal antibody to survivin. Survivin expression was described as absent or weak and strong. Results Cytoplasmic and nuclear survivin expression was seen in 26 and 22 patients respectively. Strong cytoplasmic survivin expression was seen in 12 cases and strong nuclear survivin in 8. Patients with strong nuclear survivin had a median survival of 10 months, significantly lower than for patients with weak nuclear survivin expression (19months,P ＜0.05). Multivariate analysis using the Cox-propertional hazards model identified 3 important prognostic predictors: nuclear survivin (P ＜ 0.05) and presence of metastasis (P ＜0.05). Conclusion Nuclear survivin expression in cholangiocarcinoma may predict a poor prognosis.