STZ诱导构建1型糖尿病肾病动物模型 |
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引用本文: | 王晓莉,王超男,初彦辉,张涛. STZ诱导构建1型糖尿病肾病动物模型[J]. 牡丹江医学院学报, 2014, 0(3): 4-7 |
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作者姓名: | 王晓莉 王超男 初彦辉 张涛 |
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作者单位: | [1]佳木斯大学基础医学院生物化学与分子生物学系,黑龙江佳木斯154007 [2]牡丹江医学院黑龙江省抗纤维化生物治疗重点实验室 ,黑龙江佳木斯154007 [3]牡丹江医学院红旗医院,黑龙江牡丹江157011 |
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摘 要: | 目的:本实验拟构建1型糖尿病肾病动物模型,为进一步进行糖尿病肾病实验研究提供基础。方法:采用STZ腹腔注射C57BL/6小鼠,观察一般情况,监测小鼠血糖、体重,检测24h尿蛋白。结果:1型糖尿病肾病动物模型构建成功。结论:采用STZ可成功诱导构建1型糖尿病肾病动物模型。
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关 键 词: | 链脲佐菌素 1型糖尿病 糖尿病肾病 |
USING STZ TO INDUCE ANIMAL MODELS WITH TYPE 1 DIABETIC NEPHROPATHY |
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Affiliation: | Wang Xiaoli etal (Department of Biochemistry and Molecular Biology, Jiamusi University, Jiamusi 154007, China) |
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Abstract: | Objective:This study intends to construct animal models with type 1 diabetes nephropathy , and provides the basis of di-abetic nephropathy experiments for further study .Methods:By intraperitoneal injection of STZ in C57BL /6 mice ,we observe wheir general condition , monitor the blood sugar and body weight , detect the protein of 24 hours urinary .Results:The animal model with type 1 diabetes nephropathy is built successfuly .Conclusion:By using STZ ,we could successfully induce animal models with type 1 di-abetic nephropathy . |
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Keywords: | streptozotocin Type 1 diabetes Diabetic nephropathy |
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