Multilayer compression bandaging in the acute phase of deep-vein thrombosis has no effect on the development of the post-thrombotic syndrome |
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Authors: | E M Roumen-Klappe M den Heijer J van Rossum H Wollersheim C van der Vleuten Th Thien M C H Janssen |
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Institution: | (1) Department of General Internal Medicine, University Medical Centre St. Radboud, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands;(2) Department of Epidemiology and Biostatistics, University Medical Centre St. Radboud, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands;(3) Department of Endocrinology, University Medical Centre St. Radboud, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands;(4) Centre of Quality of Care Research, University Medical Centre St. Radboud, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands;(5) Department of Dermatology, University Medical Centre St. Radboud, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands; |
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Abstract: | Objective The purpose of this randomized study was to evaluate the influence of immediate multilayer compression bandages before application
of elastic stockings in the acute phase of deep-vein thrombosis (DVT) on development of the post-thrombotic syndrome (PTS).
Methods Sixty-nine patients with acute symptomatic DVT were randomized to immediate bandaging (n = 34) or no bandaging (n = 35). After reduction of edema sized-to-fit elastic stockings were applied in all patients after 7–14 days. Follow-up visits
and non-invasive examinations were planned after 7, 30 and 90 days and 1 year. Venous outflow resistance (VOR) was measured
by strain gauge plethysmography. Thrombosis score (TS) and reflux were measured by duplex scanning. After one year patients
were evaluated for clinical PTS using both the clinical scale of the CEAP classification and the Villalta score. Results Improvement of clinical symptoms and decrease of leg circumference was better on day 7 in the bandaging group, but after
1 and 3 months clinical symptoms had improved equally in both groups. In 7 patients in the no-bandaging group a bandage was
applied after all because of persistent edema after 10 days. There were no differences in VOR, TS and reflux. Using the CEAP
classification the incidence of PTS was 39% in patients with bandages and 42% in patients without bandages (RR 0.91, 95% CI
0.50–1.66). Using the Villalta score the incidence of PTS was resp. 29 and 33% (RR 0.87, 95% CI 0.41–1.8). There was no difference
in severity of PTS. Conclusion Immediate multilayer compression bandaging in the acute phase of DVT is effective in reducing edema and complaints in the
first week, but has no effect on thrombus regression, valve incompetence and the development of clinical PTS after 1 year. |
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Keywords: | Deep-vein thrombosis Post-thrombotic syndrome Compression bandaging |
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