Thymidine phosphorylase/platelet-derived endothelial cell growth factor (PD-ECGF) associated with prognosis in renal cell carcinoma |
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Authors: | K Suzuki T Morita S Hashimoto A Tokue |
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Institution: | (1) Department of Urology, Jichi Medical School, 3311-1, Yakushiji, Minamikawachi-machi, Kawachi-gun, Tochigi, 329-0498, Japan Tel.: +81-285-58-7379; Fax: +81-285-40-6595, JP |
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Abstract: | We investigated the correlation between thymidine phosphorylase (TP)/platelet-derived endothelial cell growth factor (PD-ECGF)
expression, angiogenesis, and prognosis in renal cell carcinoma (RCC) patients. We prepared paraffin block specimens from
56 postradical nephrectomy RCC patients. The preparations were immunohistochemically stained using anti-CD34 antibody and
anti-TP antibody. Angiogenic findings were evaluated based on both microvessel density (MVD) and renal arteriography findings
as classified by Roosen et al. TP expression showed heterogeneity in 56 patients: 11 (19.6%) were negative, 28 (50.0%) weak,
and 17 (30.4%) positive. There was no correlation between TP expression, MVD, and renal arteriography. There was no TP expression
in chromophobe types. Univariate analysis showed a significant correlation between survival and TP expression, patient age,
tumor infiltration type, pathologic T- and N-stages, venous involvement, distant metastasis, and tumor grade. There was no
correlation between survival and MVD or renal arteriography. Multivariate analysis showed a significant correlation between
survival and pathologic T-stage, distant metastasis, tumor infiltration type, and TP expression. TP expression in RCC may
be an independent prognostic factor rather than just an index for angiogenesis.
Received: 26 June 2000 / Accepted: 11 October 2000 |
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Keywords: | Thymidine phosphorylase Microvessel density Renal arteriography Renal cell carcinoma Prognosis |
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