| bFGF及PDGFR表达与肾移植慢性排斥血管病变和肾小球损？… |
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| 引用本文： | 姚华强,于永纲.bFGF及PDGFR表达与肾移植慢性排斥血管病变和肾小球损？…[J].中华泌尿外科杂志,2000,21(9):524-526. |
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| 作者姓名： | 姚华强 于永纲 |
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| 作者单位： | 桂林市解放军第一八一医院泌尿外科,广西 |
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| 摘 要： | 目的 探讨碱性成纤维细胞生长因子（ｂＦＧＦ）及血小板源性生长因子受体（ＰＤＧＦＲ）的表达与肾移植慢性排斥反应血管病变及肾小球损伤之间的关系。方法 采用免疫组化ＳＰ法检测２３例排斥肾组织、１２例正常肾组织、１４例远离癌的正常肾组织血管及肾小球中ｂＦＧＦ及ＰＤＧＦＲ的表达。结果 ｂＦＧＦ及ＰＤＧＦＲ在排斥组织血管平滑肌细胞、内膜层及肾小球中的表达明显高于正常组织及癌组织（Ｐ〈均０．０１）。结论 ｂＦＧ
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| 关 键 词： | 肾移植 移植物排斥 血管病变 肾小球损伤 bFGF |
| 修稿时间： | 1999-09-17 |
The role of bFGF and PDGFR expressions in vasculopathy and glomerular injury in chronic human renal allograft rejection tissues |
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| YAO Huaqiang,YU Yonggang,LI Xuede,et al..The role of bFGF and PDGFR expressions in vasculopathy and glomerular injury in chronic human renal allograft rejection tissues[J].Chinese Journal of Urology,2000,21(9):524-526. |
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| Authors: | YAO Huaqiang YU Yonggang LI Xuede |
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| Institution: | YAO Huaqiang,YU Yonggang,LI Xuede,et al.Department of Urology,the 181th Hospital of PLA,Guilin 541002,China |
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| Abstract: | Objective To elucidate the relationship between PDGFR,bFGF expressions and the vasculopathy,glomerular injury in chronic human renal allograft rejection. Methods PDGFR and bFGF expressions were studied in 23 human chronic renal allograft rejection tissues,12 normal kidney tissues and in 14 renal tissues adjacent to renal carcinoma by means of immunohistochemistry SP method. Results Both the 2 expressions were significantly higher in the glomeruli,vascular smooth musculature and intima of the chronic renal allograft rejection tissues than those in the normal renal tissues and in renal tissues adjacent to malignant growths ( P <0.01). Conclusions PDGFR and bFGF expressions could modulate the normal glomerular and vascular tissues.Over-expression of the two may take a part in the vasculopathy and glomerular injury in chronic human renal allograft rejection. |
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| Keywords: | Kidney Transplantation Graft rejection |
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