Synthesis and antibacterial activity of 1 beta-methyl-2-(5-substituted imidazolino pyrrolidin-3-ylthio)carbapenem derivatives |
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Authors: | Oh Chang-Hyun Lee Chang-Sik Lee Jong-Sun Cho Jung-Hyuck |
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Affiliation: | Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul 130-650, Korea. choh@kist.re.kr |
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Abstract: | The synthesis of a new series of 1 beta-methylcarbapenems containing a substituted imidazolino pyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of the substituent on the imidazoline ring was investigated. Compound 13 g which has a N-sulfonylmethyl substituted imidazoline moiety showed the most potent antibacterial activity. |
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Keywords: | 1β‐Methylcarbapenem Antibacterial activity Substituent effect |
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