A case of papillary meningioma with a t(1;4)(q44;q21) |
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Authors: | Go Y Ohjimi Y Iwasaki H Oka K Ishiguro M Kaneko Y Tsuchimochi H Tomonaga M Kikuchi M |
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Affiliation: | Department of Pathology, Fukuoka University School of Medicine, Fukuoka, Japan. |
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Abstract: | We report the results of cytogenetic analyses of three cases of meningiomas. The first case, a papillary meningioma, showed only one cytogenetic abnormality, 46,XX,t(1;4)(q44;q21). In contrast, the other two benign fibroblastic meningiomas showed loss of chromosome 22. Loss and/or rearrangement of chromosomes other than chromosome 22 appears to be associated with a more aggressive clinical course. It is suggested that a sole cytogenetic abnormality with a normal chromosome 22 indicates an atypical nature of meningioma. |
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