重度非增生型糖尿病视网膜病变多焦视网膜电图与光学相干断层扫描的图像特征及临床意义

[目的]观察重度非增生型糖尿病视网膜病变（NPDR）的多焦视网膜电图（mfERG） 及视网膜光学相干断层扫描（OCT）的图像特征及临床意义.[方法]对临床确诊的重度NPDR 患者组20例（25只眼）和正常对照组20例（20只眼） 进行mfERG与OCT检查,并对所得数据进行统计分析.[结果]重度NPDR患者组mfERG 2-5环的反应密度均低于正常对照组,且有显著性差异（P〈0.05）,N1波潜伏期在4环、P1波潜伏期在3~5环与正常对照组相比显著延长（P〈0.05）.重度NPDR患者组OCT显示视网膜黄斑中心凹厚度平均值高于正常对照组,差异有统计学意义.[结论]MfERG可有效地评价重度NPDR患者黄斑区视网膜的功能,重度NPDR患者OCT断层扫描像与其已知的视网膜病变特点相一致.

Observation on Multifocal Electroretinogram and Optical Coherence Tomography in Nonproliferative Diabetic Retinopathy

[Objective] To observe the image characteristics of multifocal electroretinogram（mf-ERG） and optical coherence tornography（OCT） in patients with severe nonproliferative diabetic retinopathy（NPDR） and its clinical significance. [Methods] The mf-ERG and OCT examination were performed for 20 severe NPDR patients（25 eyes） confirmed by clinical diagnosis and 20 normal control subjects（20 eyes）. The data were analyzed statistically. [Results]The response density of ring 2-5 of mffERG in severe NPDR group were lower than those in control group, and there was significant difference. Compared with control group, the latency of N1 wave at ring 4 and P1 wave at ring 3-5 were prolonged. OCT showed that the average retinal thickness of central fovea macula in severe NPDR group was higher than that in control group, and there was significant difference. [Conclusion] The mf-ERG can effectively evaluate retinal function at macular area in severe NPDR patients. OCT images in severe NPDR patients concord with known pathological features of retina.