丙泊酚复合芬太尼麻醉联合米索前列醇在无痛钳刮术中的应用研究

目的探讨丙泊酚复合芬太尼麻醉联合米索前列醇用于无痛钳刮术的临床疗效。方法将486例孕11～14周且要求无痛终止妊娠的孕妇随机分为观察组246例和对照组240例。观察组采用丙泊酚复合芬太尼麻醉联合术前米索前列醇口服行无痛钳刮术,对照组单纯采用丙泊酚复合芬太尼麻醉行无痛钳刮术。观察并比较2组镇痛效果、宫颈松弛度、人工流产综合征发生情况、手术时间及术中出血量。结果 2组均无自述疼痛感觉及人工流产综合征发生。观察组无阻力扩宫率为79.7%,高于对照组的37.1%;手术时间短于对照组,术中出血量少于对照组,差异均有统计学意义(P<0.01)。结论丙泊酚复合芬太尼麻醉联合米索前列醇应用于无痛人工流产钳刮术,具有镇痛效果好、手术时间短、术中出血量少、安全快速等特点,值得临床推广应用。

Application research of Propofol and fentanyl anesthesia combined with misoprostol in painless curettage

Objective To investigate the effect of Propofol and fentanyl anesthesia combined with misoprostol in painless curettage.Methods 486 cases of pregnancy of 11 to 14 weeks and with the requirements of painless induced abortion of pregnant women were randomly divided into the observation group of 246 cases and control group of 240 cases.The observation group was treated with propofol and fentanyl anesthesia combined with misoprostol before undergoing painless curettage,the control group was treated with propofol and fentanyl anesthesia in painless curettage.Analgesia,cervix relaxation,abortion syndrome,operation time and the amount of bleeding in operation were observed and compared.Results Both groups had no self-reported pain sensation and abortion syndrome.No-resistance dilation rate in the observation group was 79.7%,higher than that of control group(37.1%);operation time was shorter than the control group,the bleeding amount less than that in the control group,and the difference was statistically significant(P<0.01).Conclusion Propofol fentanyl anesthesia used in painless artificial abortion with misoprostol has good analgesic effect,less bleeding,less adverse reaction,safe and fast,worthy of clinical application.