盐酸依匹斯汀联合西咪替丁治疗慢性荨麻疹疗效观察

【目的】观察盐酸依匹斯汀联合西咪替丁治疗慢性荨麻疹（CU）疗效。【方法】选择CU患者120例，随机分为治疗组和对照组各60例，对照组给予盐酸依匹斯汀口服，每次20mg，每日1次；治疗组在对照组用药的基础上给予西咪替丁口服，每次200mg，每日2次。4周为一个疗程。比较两组的疗效及不良反应。【结果】治疗组治愈率为88．3％（53／60）显著高于对照组71．7％（43／60）（P〈0．05）；治疗组的药物不良反应率（8．33％）与对照组（6．67％）比较差异无显著性（P〉0．05）。【结论】盐酸依匹斯汀联合西咪替丁治疗CU安全有效，值得在临床推广。

Observation of the Efficacy of Epinastine Hydrochloride Combined with Cimetidine for the Treatment of Chronic Urticaria

Objective] To observe the clinical efficacy of epinastine hydrochloride combined with cimeti- dine for the treatment of chronic urticaria（CU）. Methods] Totally 120 CU patients were randomly divided in- to treatment group and control group with 60 cases in each group. Control group was given oral epinastine hydrochloride 20mg per day. Treatment group was given oral cimetidine 200mg twice daily based on the medi- cation of control group. Both groups were treated for 4 weeks. The clinical efficacy and adverse drug reactions were compared between two groups. Results] The cure rate of treatment group was 88.3% （53/60）, which was significantly higher than that of control group（71.7%, 43/60）（ P〈0.05）. There was no significant difference in adverse drug reaction rate between two groups（8.33% vs 6.67%）（ P 〉0.05）. Conclusion] Epinastine hydrochloride combined with cimetidine for the treatment of chronic urticaria is safe and reliable, so it is worthy of clinical generalization.