参附注射液抗膈肌疲劳的实验研究

目的：研究参附注射液对兔膈肌功能的影响。方法：以跨膈压（Ｐｄｉ）、膈肌肌电图（ＥＭＧｄｉ）及膈肌诱发电位（ＤＥＰ）为指标，双侧膈神经刺激３０ｍｉｎ复制膈肌疲劳（ＤｉＦ），于用药前及用药后记录不同刺激频率的Ｐｄｉ、ｄＥＭＧｄｉ及ＤＥＰ，算出高／低频（Ｈ／Ｌ）比值和中心频率（Ｆｃ），数据经方差分析ｑ检验。结果：参附注射液２ｍｌ／ｋｇ用药后３０ｍｉｎ可提高Ｐｄｉ、Ｈ／Ｌ比值、Ｆｃ和ＤＥＰ幅度，缩短ＤＥＰ

Experimental Study on Anti-fatigue Effect of Shenfu Injection on Diaphragmatic Muscle

To study the effect of Shenfu injection (SFI) on function of diaphragmatic muscle in rabbits.Methods: Taking the transdiaphragmatic pressure (Pdi), diaphragmatic electromyogram (EMGdi). and diaphragmatic evoked potential (DEP) as criteria for observation, the diaphragmatic fatigue (DiF) was induced by stimtilating bilateral phrenic nerve for 30 minutes. Pdi, EMGdi and DEP induced by stimulation with different frequency (Fc) were recorded be fore and after treatment. Then the high/low (H/L) frequency ratio and central Fc were calculated and analysed by variance analysis and q test. Results: After administration of 2 ml/kg of SFI, the Pdi, H/L, Fc and amplitude of DEP were markedly increased and latent phase of DEP was shortened by the drug, in comparing with those before treatment, P <0.05. Conclusion: SFI has the effect in antagonizing diaphragmatic fatigue.