| 颅脑创伤后强迫症患者血小板5-羟色胺水平的对照研究 |
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| 引用本文： | 杨永林,庄须伟,王兴强,王善仕,尹红霞. 颅脑创伤后强迫症患者血小板5-羟色胺水平的对照研究[J]. 中华行为医学与脑科学杂志, 2010, 19(12). DOI: 10.3760/cma.j.issn.1674-6554.2010.12.008 |
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| 作者姓名： | 杨永林 庄须伟 王兴强 王善仕 尹红霞 |
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| 摘 要： | 目的 探讨颅脑创伤后强迫症患者血小板5-羟色胺(5-HT)水平.方法 测定符合诊断标准的27例颅脑创伤后强迫症患者(强迫症组)和27名颅脑创伤后非强迫症患者(对照组)的血小板5-HT水平.结果 颅脑创伤后强迫症组血小板5-HT水平[(139±172)μg/L]低于正常人组[(248±215)μg/L],差异具有显著性(P＜0.05).结论 强迫症患者症状与5-HT浓度变化有相关性;单纯强迫思维者的5-HT浓度与单纯强迫动作患者的差异有显著性.
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| 关 键 词： | 强迫性障碍 血清素 |
A comparative study of platelet serotonin in patients after traumatic brain injury with obsessive compulsive disorder |
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| YANG Yong-lin,ZHUNAG Xu-wei,WANG Xing-qiang,WANG Shan-shi,YIN Hong-xia. A comparative study of platelet serotonin in patients after traumatic brain injury with obsessive compulsive disorder[J]. Chinese Journal of Behavioral Medicine and Brain Science, 2010, 19(12). DOI: 10.3760/cma.j.issn.1674-6554.2010.12.008 |
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| Authors: | YANG Yong-lin ZHUNAG Xu-wei WANG Xing-qiang WANG Shan-shi YIN Hong-xia |
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| Abstract: | Objective To explore the role of serotonin(5-HT) in obsessive compulsive disorder(OCD) and the difference in platelet 5-HT content between OCD and healthy controls, the obsession and the compulsion subgroup. Methods The concentration of serotonin (5-HT) in twenty-seven patients with OCD and twenty-seven patients without OCD were detected in the study. Results Platelet serotonin level in patients with OCD ( ( 139 ±172 ) μg/L) was lower than that in patients without OCD ( ( 248 ± 215 ) μg/L), and the differences were significant (P＜0.05). Conclusion The present results support the hypothesis that 5-HT hypofunctionality contribute to OCD. And the differences between the obsession and the compulsion subgroup in the role of 5-HT are significant. |
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| Keywords: | Obsessive-compulsive disorder Serotonin |
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