Theophylline absorption in young asthmatic children receiving sustained-release formulations |
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Authors: | J R Haltom S J Szefler |
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Institution: | 1. Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado USA;2. Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado USA;3. Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado USA |
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Abstract: | Theophylline absorption from sustained-release formulations intended for administration every 8 hours and every 12 hours was examined in children ages 2 to 6 years during multiple dosing intervals. By generally applied measurements, including mean serum theophylline concentration, bioavailability over a single daytime dosing interval, and percent change in serum theophylline concentration over a single dosing interval, the preparations did not differ. However, over multiple dosing intervals, the 8-hour preparation varied in rate and extent of absorption, with subsequent large variations in serum theophylline concentrations. The 12-hour preparation, on the other hand, was completely bioavailable during each dosing interval, although the rate of absorption did differ from day to night, and was associated with generally acceptable changes in serum concentrations. Thus, analysis of dose-to-dose absorption was required to reveal the differences between the two study preparations. This indicates that traditional analysis of a single daytime dosing interval may be inadequate in the evaluation of preparations of sustained-release theophylline. |
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Keywords: | Reprint requests: Stanley J Szefler M D Department of Pediatrics National Jewish Center for Immunology and Respiratory Medicine 3800 E Colfax Ave Denver CO 80206 |
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