雌、孕激素受体在非小细胞肺癌中的表达及意义

目的　探讨雌激素受体 (ER)、孕激素受体 (PR)在非小细胞肺癌组织中的表达情况。方法　应用S P免疫组化法检测石蜡包埋的肺癌标本中ER、PR。结果　ER、PR的阳性表达率分别为 4 5 .2 %、4 0 .4 % ,其中腺癌的表达明显高于其他组织类型 ;ER、PR的表达与患者的性别、年龄、临床分期、肿瘤细胞分化水平无关 ;1年和 3年术后ER与PR阴阳性患者的非肿瘤生存率差异无统计学意义 (P >0 .0 5 )。结论　肺癌组织中存在ER、PR ,将其作为激素辅助治疗的一个指标 ,有一定的应用前景。

Expression and significance of estrogen receptor,progesterone receptor in non-small cell lung cancer

Objective To investigate the correspondence between the expression of estrogen receptor(ER),progesterone receptor(PR) in non-small lung cancer.Methods The immunohistochemical way S-P was employed to estimate the ER and PR in non-small lung cancer.Results The positive rates of ER and PR were 45.2% and 40.4%.The expression rates of ER and PR in adeno-carcinoma were apparently higher than that in other types of lung cancer tissues (P< 0.01).In lung cancer the expressions of ER and PR were not related to the sex,age,clinical stage,degree of differentiation of tumor cells(P> 0.05).There was no apparent difference in statistics of the non-tumor survival rate between the positive and negative ER and PR patients with in one,three postoperative years(P> 0.05).Conclusion ER and PR are present in lung cancer,they can be an index as a steroid-aided therapy with a good prospect.