Experience with daily immunotherapy in 59 adult allergic patients

Fifty-nine adult men with seasonal allergic rhinitis received immunotherapy that was administered five to six times per week until maintenance doses were achieved. Immunologic response was monitored with titrated prick skin tests, which revealed increased sensitivity at 2 wk, followed by progressive decline coinciding with a rise in IgG blocking antibody. Specific serum IgE (RAST) did not change. When compared with a group receiving conventional weekly injections, these subjects required the same number of injections to reach maintenance and had the same incidence of adverse reactions.