A novel synthesis of heterocyclic compounds containing coumarin moiety of potential antimicrobial activity |
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| Authors: | M. E. Abd El-Fattah |
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| Affiliation: | (1) Chemistry Department, Faculty of Science, Suez Canal University, Ismalillia, Egypt |
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| Abstract: | The chemical behaviours of 4-methyl-2-oxo-2H-benzopyran-7-yl oxoacetyl hydrazine (2) towards some different reagents such as anhydride compounds, aromatic aldehydes, carbon disulphide, and nitrous acid yielded the corresponding pathalazine derivatives (3, 4, 5), hydrazone derivative (6), 1,3,4-oxadiazole derivative (7, 8, 9) and acid azide (10) respectively. Treatment of10 with absolute alcohols, amines and ethyl amino acid ester gave the corresponding carbamate derivative (11), substituted urea derivative (12) and ethyl substituted alkyl acetate (13) respectively. The biological activity of some synthesized compounds was evaluated. |
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| Keywords: | Antimicrobial activity Heterocyclic compounds Coumarin Acid azide 4-Methyl-2-oxo-2H-benzopyran-7-yl oxoacetyl hydrazine |
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