Correlation between the retinal nerve fiber layer thickness and the pattern electroretinogram amplitude |
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Authors: | Toffoli Giovanni Vattovani Odilla Cecchini Paolo Pastori Giulio Rinaldi Giorgio Ravalico Giuseppe |
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Affiliation: | Istituto di Clinica Oculistica, Università di Trieste, Ospedale Maggiore, Italia. |
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Abstract: | OBJECTIVE: To establish a correlation between the retinal nerve fiber layer (RNFL) thickness measured by a scanning laser polarimeter (GDx) and the pattern electroretinogram (p-ERG) amplitudes in a heterogeneous population sample composed of normal subjects, ocular hypertensive and glaucomatous patients. METHODS: 112 subjects were considered: 40 glaucomatous patients, 39 ocular hypertensive and 33 normal subjects. All were examined with the GDx, and the RNFL thickness was measured. A transient p-ERG was then recorded. RESULTS: A statistically significant correlation was observed between the RNFL thickness and the p-ERG amplitudes (p < 0.001) by means of linear regression analysis. CONCLUSION: We observed a strict correlation between the measurements of the RNFL thickness obtained with the GDx and the amplitude of the p-ERG signal. These techniques represent additional objective tools to detect an early glaucomatous damage. |
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