胆囊腺肌瘤病-附30例(包括1例恶变)临床病理观察

目的 分析胆囊腺肌瘤病的临床和病理特征，为该瘤；病理诊断和治疗提供依据。方法 对３０例胆囊腺肌瘤病的临床和病理进行观察与分析。结果 ８６８例手术切除胆囊标本中有胆囊腺肌瘤病３０例（３．４％），患者均为成年人（２７￣８０岁，平均５７．６岁），男女病例相等（１５：１５）。１８例（６０．０％）为局限型，多位于胆囊底部；节段型５和弥漫型分别５例和３例。各型病变均见胆囊粘膜增生、粘膜上皮下陷于肌层或肌层下形

Adenomyomatosis of the gallbladder: a clinicopathological analysis of 30 cases including one with malignant changes

Objective To investigate the clinicopathological features of adenomyomatosis of the gallbladder (GBA) to provide bases for pathological diagnosis and clinical treatment. Methods Clinical data and pathological characteristics of GBA were reviewed retrospectively in 30 cases. Results There were 30 cases of GBA found in 868 cases of the excised gallbladder specimens during 1968 - 1998 in this hospital. Grossly, there were three growth patterns of the tumor, localized, segmental and diffused types. The mucosal hyperplasia forming Rokitansky-Aschoff (R-A) sinus, and proliferation of the smooth muscles around the sinus and hypertrophy of the muscular layer were observed in all types of the lesions. In addition, one case of localized adenomyomatosis with coexisted mucinous adenocarcinoma was found, in which there was a transitional area between the adenocarcinoma and atypical hyperplastic glandular epithelium, and the epithelium with carcinomatous change was noted in a R-A sinus. Conclusions GBA is a lesion that mostly occurs in adults and frequently coexists with chronic cholecystitis and cholelithiasis, and it has a malignant potential and should be removed timely.