女性系统性红斑狼疮患者神经肽Y、神经降压素的检测及其意义

目的：探讨女性系统性红斑狼疮（SLE）患者血浆中神经肽Y和神经降压素水平的变化及其意义。方法：采用放射免疫分析法对30例女性SLE患者及20例正常对照血浆中神经肽Y、神经降压素水平进行检测。结果：女性SLE患者血浆中神经肽Y水平升高，神经降压素水平降低，二者与对照组相比，差异有显著性（P〈0．01）；与病情非活动期相比，病情活动期SLE患者神经肽Y水平显著升高、神经降压素水平显著降低，差异有显著性（P〈0．01），治疗3个月后，二种物质的水平趋于正常，与对照组相比，差异无显著性（P〉0．05）。结论：女性SLE患者血浆中神经肽Y和神经降压素水平的变化可能与SLE的发病有关．

The measurement and the significance of NPY and NT in the plasma of female patients with SLE

Objective: To measure the level of neuropeptide Y (NPY) and neurotensin (NT) in the plasma of female patients with SLE and to explore the significance in the pathogenesis of systemic lupus erythematosus (SLE). Methods: Radio-immunoassay method was employed to measure the levels of NPY and NT in the plasma of 30 SLE patients and 20 normal controls. Results: The plasma level of NPY in untreated SLE patients was higher than that in normal controls (P<0.01), while the plasma level of NT in untreated SLE was decreased compared to the normal controls (P<0.01) and in inactive stage of the disease (P<0.01). The plasma level of NPY in active stage of SLE was significantly higher (P<0.01). The plasma levels of the two kinds of neuropeptides were changed to the normal level after the treatment and there was no significant difference as compared with the normal controls (P>0.05). Conclusion: The changes of the two kinds of neuropeptides may be relevant to the pathogenesis of SLE.