碱性成纤维细胞生长因子在膀胱移行细胞癌的表达及意义

目的：研究碱性成纤维细胞生长因子（ｂＦＧＦ）在膀胱移行细胞癌（ＢＴＣＣ）的表达及其意义。方法：应用免疫组化ＡＢＣ法检测３３例ＢＴＣＣ及１２例正常膀胱组织中ｂＦＧＦ抗原。结果：ｂＦＧＦ在正常移行细胞呈阴性表达，在正常组织和肿瘤组织的血管内皮细胞、平滑肌细胞均呈弱性表达，肿瘤细胞呈不同程度的阳性表达且过表达率在不同病理分级临床分期间有显著性差异（Ｐ〈０．０５），在单发与多发、初发与复发组间无显著性差异

Expression of basic fibrobalst growth factor in human transitional cell carcinoma of bladder and its significance

Purpose:To evaluate the expression of basic fibroblast growth factor (bFGF) in human transitional cell carcinoma of bladder (BTCC) and its significance. Methods:The expression of bFGF was detected by standard ABC immunohistochemical technique in 33 paraffin embedded tissue specimens of BTCC. Results:All normal transitional cells were negatively stained. Neoplastic cells,smooth muscle cells and endothelial cells of vessels in normal and neoplastic tissue were positively stained. Fisher accurate analysis showed that moderately or strongly positive expression of bFGF in tumor cells closely correlated with different pathological grades ( P <0 05) and clinical stages ( P <0 05). But there was no significant correlation between bFGF over expression and number of lesions ( P <0 05) or postoperative reccurance ( P >0 05). Conclusions:The over expression of bFGF closely correlates with biological behaviour of BTCC and plays an important role in the process of invasiveness and metastasis. This marker may be a new target for comprehensive treatment of BTCC.