| HPLC法测定盐酸阿夫唑嗪缓释片的含量 |
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| 引用本文： | 黄元元,公方美,王文义.HPLC法测定盐酸阿夫唑嗪缓释片的含量[J].齐鲁药事,2008,27(6). |
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| 作者姓名： | 黄元元 公方美 王文义 |
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| 作者单位： | 鲁南贝特制药有限公司,山东,临沂,276006 |
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| 摘 要： | 目的建立盐酸阿夫唑嗪缓释片含量测定的高效液相色谱方法.方法色谱柱:Agilent Eclipse C18;流动相:四氢呋喃-乙腈-高氯酸钠溶液(将5mL高氯酸稀释到900mL水中,用NaOH溶液调pH值至3.5,加水至1000mL)=1∶20∶80;检测波长254nm.结果制剂中辅料和有关物质对主药无干扰,盐酸阿夫唑嗪在浓度15.0~35.5μg·mL-1范围内线性关系良好,相关系数r=0.9999(n=5);平均回收率(n=9)为100.68%(RSD=0.71%).结论本法专属性好,准确,简便.
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| 关 键 词： | 盐酸阿夫唑嗪 片剂 含量 高效液相色谱法 |
Determination of Alfuzosin Hydrochloride Sustained-release Tablets by HPLC |
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| HUANG Yuan-yuan,GONG Fang-mei,WANG Wen-yi.Determination of Alfuzosin Hydrochloride Sustained-release Tablets by HPLC[J].qilu pharmaceutical affairs,2008,27(6). |
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| Authors: | HUANG Yuan-yuan GONG Fang-mei WANG Wen-yi |
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| Abstract: | OBJECTIVE To establish an HPLC method for determination of alfuzosin in Alfuzosin Hydrochloride Sustained-release Tablets.METHODS The chromatographic column of Agilent Eclipse C18 was used.The mobile phase was consisted of tetrahydrofuran-acetonitrile-sodium perchlorate solution(Dilute 5mL perchloric in 900ml water,adjust the pH to 3.5 by dilute sodium hydroxide solution,and dilute the solution to 1000mL with water) =1∶20∶80.The detection wavelength was 254nm.RESULTS Alfuzosin and the other components in the samples were separated completely.There was a good linear relationship in the range of 15.0~35.5μg·mL-1 with the correlation coefficient of 0.9999.The average recovery of Alfuzosin tablets was 100.68%(n=9,RSD=0.71%)respectively.CONCLUSION The method was specific,accurate and simple. |
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| Keywords: | Alfuzosin tablets content HPLC |
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