| 白介素—2对吗啡镇痛作用不敏感大鼠的镇痛效应 |
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| 作者姓名： | Song P Liu XY Zhao ZQ |
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| 作者单位： | 中国科学院上海生命科学研究院生理研究所,中国科学院上海生命科学研究院生物化学与细胞生物学研究所,复旦大学神经生物学研究所 上海,中国 200031,上海 200433 |
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| 摘 要： | 目的:研究白介素-2在经完全福氏佐剂处理的、对吗啡镇痛作用不敏感大鼠上的镇痛作用.方法:以由伤害性热刺激所引起的抬腿潜伏期作为大鼠痛阈来研究药物的镇痛作用.结果:在正常大鼠足底局部注射人重组白介素-2(1.5×10~4 U)能够显著提高痛阈,此镇痛作用被μ-阿片肽受体的拮抗剂纳络酮(1 mg/kg,ip)部分翻转.在对吗啡不敏感的经福氏佐剂处理的动物上,白介素-2仍具有显著的镇痛作用,但较之于在正常动物上的则明显降低.在经完全福氏佐剂处理的动物上,纳络酮不对白介素-2的镇痛作用产生影响.结论:μ-阿片肽受体部分介导了白介素-2的镇痛作用;白介素-2具有潜在的临床应用价值以治疗对吗啡不敏感的疼痛.
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| 关 键 词： | 抗痛效应 白介素-2 μ-阿片受体 |
Interleukin-2-induced antinociception in morphine-insensitive rats |
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| Song P,Liu XY,Zhao ZQ.Interleukin-2-induced antinociception in morphine-insensitive rats[J].Acta Pharmacologica Sinica,2002,23(11):981-984. |
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| Authors: | Song Ping Liu Xin-Yuan Zhao Zhi-Qi |
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| Institution: | Institute of Neurobiology, Fudan University, Shanghai 200433, China. |
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| Abstract: | AIM: To investigate interleukin-2-induced antinociception in morphine-insensitive rats. METHODS: Paw withdrawal latencies (PWL) to noxious radiant heat were taken as the measurement of pain threshold. RESULTS: Intraplantar injection of human recombinant interleukin-2 (1.5 x10(4) U) significantly increased PWL in normal rats. PWL was also markedly increased by IL-2 in 45-d-post-complete Freund's adjuvant (CFA)-treated rats, which have been proven morphine-insensitive. IL-2-induced antinociception in CFA-treated rats were significantly lower than that in normal rats. IL-2-induced antinociception was partially blocked by naloxone (1 mg/kg, ip) in normal rats but remained unchanged in CFA group. CONCLUSION: IL-2-induced antinociception is partially mediated by mu-opioid receptors. Therapeutic applications of IL-2 may also be expanded to relieve morphine-insensitive pain. |
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