| 血液高凝状态加重糖尿病肾病肾功能障碍 |
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| 引用本文： | 孙雪峰,周希静,严海东,王力宁. 血液高凝状态加重糖尿病肾病肾功能障碍[J]. 中华血液学杂志, 2001, 22(9): 476-477 |
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| 作者姓名： | 孙雪峰 周希静 严海东 王力宁 |
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| 作者单位： | 1. 中山医科大学附属第一医院肾科,
2. 中国医科大学附属第一医院肾科 |
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| 摘 要： | 目的 探讨糖尿病肾病患者血液高凝状态与肾功能的关系。方法 46例伴有肾病综合征的糖尿病肾病患者，以24h内生肌酐清除率分为高（H）、中（M）和低（L）三组，并对其中14例实施华法林治疗。系统检测凝血、纤溶及肾功指标。结果 伴随肾病进展，凝血活性进一步亢进；华法林治疗改善高凝状态后，可降低肾病恶化速度。结论 血液高凝状态是糖尿病肾病患者肾功能障碍的原因之一。
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| 关 键 词： | 血液凝固 糖尿病肾病 肾功能障碍 华法林 治疗 |
| 修稿时间： | 2001-02-26 |
Hypercoagulation aggravates renal dysfunction in patients with diabetic nephropathy |
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| X Sun,X Zhou,H Yan. Hypercoagulation aggravates renal dysfunction in patients with diabetic nephropathy[J]. Chinese Journal of Hematology, 2001, 22(9): 476-477 |
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| Authors: | X Sun X Zhou H Yan |
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| Affiliation: | Department of Nephrology, First Affilliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510080, China. |
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| Abstract: | OBJECTIVE: To investigate the relationship of hypercoagulation and renal dysfunction in patients with diabetic nephropathy(DN). METHODS: Forty six diabetes type II patients with nephrotic syndrome were divided into 3 groups according to 24 hr creatinine clearance (Ccr) as high, middle and low groups. Fourteen of the 46 patients received warfarin therapy. The parameters of coagulation and fibrolysis as well as renal function were examined. RESULTS: Patients with moderate and major renal dysfunction (M group and L group) displayed higher activities of coagulation than those with mild renal dysfunction (H group) did. Warfarin could obviously improve the status of coagulation and fibrolysis in patients with DN and delay the progress of renal dysfunction. CONCLUSION: Hypercoa-gulation was one of the causes of renal dysfunction in patients with DN. |
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| Keywords: | Hypercoagulation Diabetes Renal function |
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