Genetic mapping ofPim-1 putative oncogene to mouse chromosome 17 |
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| Authors: | John Hilkens H. Theo Cuypers Gerard Selten Vera Kroezen Jo Hilgers Anton Berns |
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| Affiliation: | (1) Department of Tumor Biology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Plesmanlaan 121, 1066 CX, Amsterdam;(2) Department of Biochemistry, University of Nijmegen, Geert Grooteplein N 21, 6521 EZ, Nijmegen, The Netherlands |
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| Abstract: | Pim-1 is a putative oncogene activated in T-cell lymphomas induced by Moloney and AKR mink cell focus forming (MCF) viruses. We have determined the chromosomal localization of the Pim-1gene in mice by Southern blot analysis of DNAs obtained from a panel of mouse-Chinese hamster somatic cell hybrids. The Pim-1gene was localized on chromosome 17, a chromosome frequently aberrant in T-cell lymphomas. Two chromosomal regions, containing sequences homologous to regions within the Pim-1locus, were localized on chromosome 6 and 16. |
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