| mTOR信号通路与胰岛素抵抗的关系及运动的影响 |
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| 引用本文： | 傅力,刘效磊,苑红,牛燕媚.mTOR信号通路与胰岛素抵抗的关系及运动的影响[J].国际内分泌代谢杂志,2009,29(6). |
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| 作者姓名： | 傅力 刘效磊 苑红 牛燕媚 |
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| 作者单位： | 1. 300381,天津体育学院健康与运动科学系,天津市运动生理与运动医学重点实验室;300070,天津医科大学康复与运动医学系
2. 天津市运动生理与运动医学重点实验室,天津体育学院健康与运动科学系,300381 |
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| 基金项目： | 国家自然科学基金，天津市应用基础与前沿项目重点课题，天津市重大攻关项目 |
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| 摘 要： | 哺乳动物雷帕霉素靶蛋白(mTOR)是细胞内感受细胞外营养、能量水平以及生长因子等信号变化的一种丝/苏氨酸蛋白激酶,参与凋节细胞生长、分化、增殖以及蛋白质合成等过程,并且与胰岛素抵抗(IR)的发生、发展关系密切.本文对mTOR/S6K1信号通路的调控机制与IR发生、发展过程的关系,以及运动对mTOR信号通路的影响加以综述,以期为探寻合理的运动手段以及药物作用靶点作为治疗由细胞代谢紊乱引起的IR、2型糖尿病等代谢性疾病提供理沦依据.
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| 关 键 词： | 哺乳动物雷帕霉素靶蛋白 胰岛素抵抗 运动 |
mTOR signaling pathway in the development of insulin resistance and the effects of exercise |
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| FU Li,LIU Xiao-lei,YUAN Hong,NIU Yan-mei.mTOR signaling pathway in the development of insulin resistance and the effects of exercise[J].International JOurnal of Endocrinology and Metabolism,2009,29(6). |
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| Authors: | FU Li LIU Xiao-lei YUAN Hong NIU Yan-mei |
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| Abstract: | The mammalian target of rapamycin (mTOR) is one of the Ser/Thr protein kinases that functions as a key integrator of signaling from nutrients,energy and growth factors.mTOR integrates extensive biological process including cell growth,proliferation and protein synthesis etc,and has a close relationship with the development of insulin resistance(IR).This article summarized the recent studies about the regulation mechanism of mTOR/S6K1 and its relationship with the development of IR,and the effects of exercise on mTOR signaling pathway,inorder to provide theory basis for searching possible exercise forms and pharmaceutical targets in treating the metabolic diseases like 1R and type 2 diabetes which ale induced by disturbance of cell metabolism. |
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| Keywords: | Mammalian target of rapamycin Insulin resistance Exercise |
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