| 铅作业工人尿N-乙酰-β-D-氨基葡糖苷酶同工酶活性的研究 |
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| 引用本文： | 何兴轩,凌之琰,罗莎菲,陈安朝.铅作业工人尿N-乙酰-β-D-氨基葡糖苷酶同工酶活性的研究[J].中国职业医学,1993(6). |
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| 作者姓名： | 何兴轩 凌之琰 罗莎菲 陈安朝 |
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| 作者单位： | 湖南医科大学环境医学研究室，湖南医科大学劳动卫生教研室，湖南医科大学劳动卫生教研室，湖南医科大学劳动卫生教研室 长沙市北站路 410078，长沙市北站路 410078，长沙市北站路 410078，长沙市北站路 410078 |
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| 摘 要： | 本文对227名铅作业工人的肾功能和卟啉代谢状况进行了研究。结果表明卟啉代谢紊乱先于铅中毒性肾损害,铅接触组的尿NAG-A活性显著低于对照组,而尿NAG-B无明显变化;尿NAG-A活性下降是反映铅中毒性肾损害较敏感的指标,其检测价值比尿总NAG测定大。尿NAG-A活性检测可作为铝中毒性肾损害的监测指标。
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| 关 键 词： | 铅 尿NAG同工酶 尿酶 肾脏毒性 卟啉代谢 |
Study on N-acetyl-beta-D-glucosaminidase isoenzyme in urine of workers exposed to lead. |
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| He Xingxuan.Study on N-acetyl-beta-D-glucosaminidase isoenzyme in urine of workers exposed to lead.[J].China Occupational Medicine,1993(6). |
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| Authors: | He Xingxuan |
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| Institution: | He Xingxuan |
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| Abstract: | The renal function and porphyrin meta bolism of 227 workers exposed to lead were investigated. It was found that the activity of N-acetyl-beta-D-glucosaminidase (NAG) type A in urine of exposed workers was lower than control group, whereas type B showed no significant difference comparing with control group. Urinary NAG type A was one of the most sensitive parameters that showing lead-induced renal damage and was more significant than total urinary NAG in this aspect. Disorder of porphyrin metabolism occured earlier than lead-induced renal damage. Urinary NAG type A, however, could be a monitoring parameter of lead-induced renal damage. |
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| Keywords: | lead renal urinary enzymes nephrotoxicity porphyrin metabolism |
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