Hyaluronan, CD44, and cyclooxygenase-2 in colon cancer |
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| Authors: | Misra Suniti Hascall Vincent C Berger Franklin G Markwald Roger R Ghatak Shibnath |
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| Affiliation: | Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA. misra@musc.edu |
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| Abstract: | Carcinomas arising from colon epithelia develop or progress in a stromal microenvironment that is elevated in hyaluronan; interactions between elevated hyaluronan and the CD44 receptors on epithelial tumor cells activate an HA-receptor tyrosine kinase-mediated cell survival pathway. In this review we provide evidence that the hyaluronan-ErbB2-PI3kinase/AKT-ss-catenin-COX-2 signaling axis leads to intestinal epithelial and colon tumor cell division and proliferation. This review includes a summary of the authors work over the past years as well as citations of specific reviews related to role of hyaluronan in the pathogenesis of colon cancer. |
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