Induction of Ia antigens on thyroid cultures by syngeneic T lymphocytes: a model of autoimmune disease |
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Authors: | J Salamero J Charreire |
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Affiliation: | INSERM U. 283, Hôpital Cochin, 27, rue du Faubourg Saint-Jacques, 75674 Paris Cedex 14, France |
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Abstract: | We previously reported that the expression of Ia antigens on cultured monolayers of murine thyroid epithelial cells (TEC) occurred with a particular distribution exclusively on the basal part of the cultured thyroid cells, while class I antigens of the major histocompatibility complex (MHC) are only detected on the apical surface. It appears that deposition of syngeneic lymphocytes induces, 24 h later, Ia expression on the apical side of cultured TEC, the surface that is in direct contact with the responder lymphocytes during syngeneic sensitization of T lymphocytes. We hypothesized that this phenomenon could represent, in syngeneic situations, the restriction process in antigen recognition by T cells, as demonstrated by Ia restricted primary syngeneic sensitization (PSS) on murine TEC. |
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Keywords: | thyroid autoimmunity Ia antigens t lymphocytes |
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