HBV、HCV和HGV的感染对HCC家庭聚集性的影响

为了研究乙、丙、庚型肝炎病毒感染在原发性肝癌家庭聚集性中的作用，本文应用PCR方法对肝癌病、低发家庭成员进行了HBV-DNA、HCV-RNA和HGV-RNA检测。结果发现，高发户成员和无癌户成员中HBV-DNA和HGV-RNA的阳性率分别为21．8％（12／55）、36．4％（20／55）和7．3％（4／55）、14．5％（8／55）（P＜0．01）。HCV-RNA阳性率分别为10．9％（6／55）和21．8％（12／55）（P＞0．05）。HBV＋HCV、HCV＋HGV、HGV＋HBV、HBV＋HCV＋HGV的重叠感染率分别为3．6％（2／55）、3．6％（2／55）、14．5％（8／55）、3．6％（2／55）和1．8％（1／55）、9．1％（5／55）、1．8％（1／55）、0．0％（0／55），其中HBV＋HGV重叠感染模式两组有明显差异（P＜0．05），其余各模式无明显差异。结果提示，HBV和HGV的感染可能是HCC家庭聚集原因之一，而HBV＋HGV重叠感染模式较其他模式与HCC家庭聚集性关系更为密切。

Effect on the famillal cluster of HCC by chronic inrection or HBV, HCV and HGV

110 serologic specimens were collected: 55 from the families with two or even more HCC cases before (group 1); 55 from the families without hepatoma occurrence (group 2). HBVDNA was detected by PCR, HCV-RNA and HGV-RNA by RT-PCR. The detection showed that the positive rate of HBV-DNA and HGV-RNA was 21. 8% and 36. 4% in group 1 respectively,significantly higher than that of group 2 (7. 3% and 14. 5%, 8/55) (P< 0. 01). Unsignificant difference of HCV-RNA between the two groups was seen. Superinfection rate of HBV and HCV,HCV and HGV, HBV and HGV, HBV and HCV and HGV in group 1 was 3. 6%, 3. 6%, 14. 5%,3. 6 % respectively, excepting of HCV and HGV, unsignificantly higher than that of group 2 (1. 8 %,9. 1 %, 1. 8%, 0. 0%). The result suggests that the chronic infection of HGV and HBV is the important risk factors in the familial culster of HCC. HGV may be another important virus relating to the occurrence of HCC.