| Abstract: | Experiments on cats showed that injury to the medial forebrain bundle (MFB) and to some extent of the preoptic region (PR) also on the side of application of strychnine to the cerebral cortex (middle suprasylvian gyrus) causes depression of seizure activity (spike potentials) in the  strychnine focus and also in a secondary mirror focus in the symmetrical zone of the cortex of the opposite hemisphere. The same effect could be obtained in some cases after injury to MFB only. Injury to MFB and to part of PR on the side of the mirror focus causes depression of spike potentials in that focus only and does not affect activity in the primary epileptiform focus. The effects described above are examined from the standpoint of the role of the determinant dispatch station (DDS) in CNS activity: The primary epileptiform focus is a hyperactive DDS which induces the appearance of secondary foci and maintains and determines the character of their activity. It can be concluded from these experimental results that MFB participates in the modulation of cortical epileptiform activity.Laboratory of General Pathology of the Nervous System, Institute of General Pathology and Pathological Physiology, Moscow. Laboratory of Electrophysiology, V. P. Filatov Institute of Eye Diseases and Tissue Therapy, Odessa. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 82, No. 10, pp. 1155–1158, October, 1976. |
