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Genetically Determined Later Puberty Impacts Lowered Bone Mineral Density in Childhood and Adulthood
Authors:Diana L Cousminer  Jonathan A Mitchell  Alessandra Chesi  Sani M Roy  Heidi J Kalkwarf  Joan M Lappe  Vicente Gilsanz  Sharon E Oberfield  John A Shepherd  Andrea Kelly  Shana E McCormack  Benjamin F Voight  Babette S Zemel  Struan FA Grant
Affiliation:1. Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA;2. Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA;3. Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA;4. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;5. Division of Endocrinology and Diabetes, Cook Children's Medical Center, Fort Worth, TX, USA;6. Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA;7. Division of Endocrinology, Department of Medicine, Creighton University, Omaha, NE, USA;8. Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA;9. Division of Pediatric Endocrinology, Diabetes, and Metabolism, Department of Pediatrics, Columbia University Medical Center, New York, NY, USA;10. Department of Radiology, University of California San Francisco, San Francisco, CA, USA;11. Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA, USA;12. Department of Systems Pharmacology and Translation Therapeutics, University of Pennsylvania, Philadelphia, PA, USA;13. Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA
Abstract:
Keywords:PUBERTY  BONE MINERAL DENSITY  GENETIC RISK SCORE  MENDELIAN RANDOMIZATION
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