纤维蛋白原和血小板平均体积与急性脑梗死相关性研究

目的:探讨纤维蛋白原(FIB)和血小板平均体积(MPV)与急性脑梗死(ACI)的关系。方法:分析429例ACI患者(ACI组)和429例非脑梗死患者(对照组)的血小板和凝血系统相关参数水平,并根据ACI组的美国国立卫生研究院卒中量表(NIHSS)评分将ACI组分为轻、中、重度亚组。结果:与对照组比较,ACI组的PLT水平显著降低(P<0.01),MPV、血小板分布宽度(PDW)及纤维蛋白原(FIB)水平显著升高(P<0.01)。多因素Logistic回归分析显示,MPV和FIB与脑梗死呈独立相关(OR=1.628,95%CI为1.427~1.857;OR=7.115,95%CI为4.981~10.164);FIB与MPV水平两者相互间无明显相关性。ACI组各亚组FIB水平两两比较差异有统计学意义(P<0.01),ACI患者FIB水平与NIHSS评分呈正相关(r=0.451,P<0.01)。结论:FIB、MPV可能为引起急性脑梗死的重要危险因素,且FIB与病情的严重程度呈显著正相关。

Correlation between Fibrinogen and Mean Platelet Volume levels and Acute Cerebral Infarction

Objective： To investigate the relationship of fibrinogen （FIB）, mean platelet volume （MPV） and acute cerebral infarction （ACI）. Methods： The level ofplatelets system platelets （PLT）, MPV, plateletcrit, platelet distri- bution width （PDW） and the coagulation system （prothrombin time, international normalized ratio, FIB, activated partial thromboplastin time） of 429 ACI cases （ACI group） and 429 cases of Non-cerebral infarction group （con- trol group） were analyzed. According to the National Institutes of Health stroke Scale （NIHSS） in ACI pa- tients, the ACI group was divided into mild, moderate and severe subgroups. Results： Compared with the con- trol group, the PLT levels were significantly lower （P〈0.01） whereas the MPV, PDW and FIB levels were signif- icantly higher （P〈0.01） in ACI group. Logistic regression analysis showed that MPV and FIB were independently associated with ACI （OR = 1.628, 95% C1：1.427-1 .857; OR = 7.115,95% CI ：4.981-10.164）. The FIB level showed no significant correlation with MPV level. The FIB levels between the subgroups of ACl group were sig- nificantly different （P〈0.01）. In ACI patients, the FIB levels and NIHSS score were positively correlated （r = 0.451, P〈0.01）. Conclusion： FIB and MPV levels may be the important risk factors for ACI.