Interferon-c and interleukin-4 detected in serum and saliva from patients with oral lichen planus |
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| Authors: | Wen-Zhao Liu Ming-Jing He Long Long Dong-Liang Mu Ming-Shu Xu Xue Xing Xin Zeng Ga Liao Hong-Xia Dan Qian-Ming Chen |
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| Institution: | Wen-Zhao Liu(College of Stomatology, Chongqing Medical University, Chongqing, China)；Ming-Jing He(State Key Laboratory of 0ral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China)；Long Long(State Key Laboratory of 0ral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China)；Dong-Liang Mu(State Key Laboratory of 0ral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China)；Ming-Shu Xu(State Key Laboratory of 0ral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China)；Xue Xing(State Key Laboratory of 0ral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China)；Xin Zeng(State Key Laboratory of 0ral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China)；Ga Liao(State Key Laboratory of 0ral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China)；Hong-Xia Dan(State Key Laboratory of 0ral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China)；Qian-Ming Chen(State Key Laboratory of 0ral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China)； |
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| Abstract: | Our previous salivary study had demonstrated an apparent T helper 2 (Th2)-predominance in saliva of oral lichen planus (OLP) patients and suggested a potential of salivary interleukin-4 (IL-4) as a biomarker for monitoring disease severity. To further determine the consistency of Th1/Th2 bias of OLP, this study investigated the expression profile of interferon-c (IFN-c) and IL-4 in serum and the relationship of the serum levels of these cytokines with their saliva partners. Sixty ethnic Chinese patients with OLP (40 of the erythematous/ulcerative form and 20 of the reticular form) were recruited for this study, with 40 age-sex-matched healthy volunteers as control group. IFN-c and IL-4 levels in serum and paired saliva samples were screened by enzyme-linked immunosorbent assay. OLP patient showed a low-level IFN-c but high-level IL-4 expression profile in both serum and saliva, with a lower IFN-c/IL-4 ratio. Serum IL-4 level in the erythematous/ulcerative group was significantly higher than that in the reticular group. Serum levels of IFN-c and IL-4 were significantly and positively correlated with their saliva partners. These results provided more evidence for Th2 cytokine-predominant immune imbalance in OLP, as well as the potential of IL-4 as the biomarker for monitoring severity of OLP. |
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| Keywords: | oral lichen planus saliva serum T helper cytokines |
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