慢性心力衰竭患者检测N-末端脑钠肽前体的临床价值 |
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引用本文: | 曾凡源,许秀定,胡民坚,李宇海,杨健希,邓曾斌,梁炯林. 慢性心力衰竭患者检测N-末端脑钠肽前体的临床价值[J]. 赣南医学院学报, 2014, 34(1): 28-30,44 |
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作者姓名: | 曾凡源 许秀定 胡民坚 李宇海 杨健希 邓曾斌 梁炯林 |
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作者单位: | 曾凡源(广东省南海区第六人民医院急诊科);许秀定(广东省南海区第六人民医院内二科,广东佛山,528248);胡民坚(广东省南海区第六人民医院急诊科);李宇海(广东省南海区第六人民医院内二科,广东佛山,528248);杨健希(广东省南海区第六人民医院急诊科);邓曾斌(广东省南海区第六人民医院急诊科);梁炯林(广东省南海区第六人民医院急诊科); |
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摘 要: | 目的:探讨检测血浆N-末端脑钠肽前体(NT-proBNP)水平对慢性心力衰竭(CHF)患者的诊断与疗效评估的临床价值。方法:将82例CHF患者按美国心脏病协会(NYHA)分级方法分为心功能Ⅱ级、Ⅲ级、Ⅳ级3组,30例健康人纳入对照组。采用胶体金免疫层析法床旁检测4组血浆NT-proBNP水平,用超声心动图测定左室舒张末期内径(LVEDD)和左心室射血分数(LVEF)。结果:CHF组NT-proBNP显著高于对照组(P〈0.01);且血浆NT-proBNP水平随着心功能分级的增加而升高(3组两两比较均有统计学意义,P〈0.05);CHF组血浆NT-proBNP浓度治疗后较治疗前降低(P〈0.05);NT-proBNP水平随着LVEDD的增大而升高(P〈0.01),随着LVEF的降低而升高(P〈0.01)。结论:血浆NT-proBNP水平可较好的反映CHF患者的心功能状态,可作为诊断CHF和判断CHF患者预后的指标。
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关 键 词: | 慢性心力衰竭 N-末端脑钠肽前体 NYHA分级 |
Clinical Value of N-terminal Pro-brain Natriuretic Peptide Levels in Patients with Chronic Heart Failure |
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Affiliation: | ZENG Fan-yuan , XU Xiu-ding , HU Min-jian , et al( 1. Department of Emergency;2. Department of Internal Medicine, The Sixth People's Hospital of Nanhai, Foshan Guangdong 528248 ) |
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Abstract: | Objective:To access the clinical associates of plasma levels of N-terminal pro-brain natriuretic peptide (NT- proBNP) and its prognostic value in patients with chronic heart failure. Methods:A total of 82 patients with CHF were recruited and classified into class II , III and IV according to New York Heart Association ( NYHA ) functional classification. Additionally ,30 healthy people were recruited as a control group. Plasma levels of NT-proBNP were determined using colloidal gold immunochromatographic assay while left ventricular end diastolic diameter (LVEDD) and left ventricle eject fraction (LVEF) were calculated according to echocardiography. Results:Levels of NT-proBNP in CHF group were significantly greater (P 〈 O. 01 ) compared to control group;it was strongly associated with the severity of cardiac status ( statistically differences were shown among class ]I , Ill and IV groups, P 〈 O. 05 ). In addition, plasma levels of NT- proBNP in patients with CHF decreased significantly ( P 〈 0.05 ) post-treatment. It was also shown that level of NT-proB- NP was in a significantly positive correlation ( P 〈 0.01 ) with LVEDD while in a significantly negative correlation ( P 〈 0.01 ) with LVEF. Conclusion:In this cohort, level of NT-proBNP is a good indicator of cardiac status of patients with CHF. This study also highlights the importance of using NT-proBNP level for both diagnosis and as prognostic indicator among patients with CHF in future. |
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Keywords: | Chronic Heart Failure N-terminal Pro-brain Natriuretic Peptide New York Heart Association (NYHA) func-tional classification |
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