成纤维细胞在银屑病发病机制中的作用

银屑病是一种以角质形成细胞的过度增殖和异常分化为特征的慢性炎症性皮肤病。银屑病全层皮肤均存在异常，多种细胞和细胞因子在银屑病发病中起重要作用。成纤维细胞作为真皮组织的重要组成部分，在皮肤组织创伤修复方面发挥作用；还为角质形成细胞的增殖、分化和成熟提供合适的微环境；可通过表达某些黏附分子、受体或表面标记及分泌多种细胞因子，影响其他细胞的功能，从而在银屑病发展中起重要的调节作用。

Roles of fibroblasts in the pathogenesis of psoriasis

Psoriasis is a chronic inflammatory dermatosis characterized by the overproliferation and impaired differentiation of epidermal keratinocytes. Abnormality exists throughout the full-thickness skin in psoriasis. Multiple types of cells and eytokines play critical roles in the pathogenesis of psoriasis. As the main constructive cell in the dermis, fibroblasts play a crucial role during cutaneous wound healing. Furthermore, fibroblasts provide favorable micro-environment for the differentiation, proliferation and maturation of keratinocytes, and modulate the function of other cells by expressing some intercellular adhesion molecules, receptors or surface markers and secreting multiple cytokines. Therefore, fibroblasts may play an important role in the pathogenesis of psoriasis.