基于经支气管镜肺减容术治疗慢性阻塞性肺疾病的临床研究进展

目的综述经支气管镜肺减容术（bronchoscopic lung volume reduction，BI,VR）治疗COPD的最新临床报道和研究进展，为COPD的临床治疗和研究思路提供更多的选择。方法对近20年来国内外发表的相关文献进行整理、分析和归纳。结果BI．VR是根据肺减容术（1ung volume reduction surgery，LVRS）原理，不需行开胸术，利用支气管镜完成肺减容的微创技术。目前常用的方法有支气管封堵法和支气管开窗法。其目的都是获得LVRS益处，而减少手术创伤、风险及长期的康复过程。结论BLVR是一种无须开胸、创伤性小的新治疗方法，在临床上大大降低了潜在的病死率和发病率，展现了巨大的临床应用前景。但由于目前还缺少大规模的随机对照临床试验结果，一些方法还处于动物实验阶段，缺乏临床研究，尚处于起步阶段。

Clinical advance of bronchoscopic lung volume reduction in treating chronic obstructive pulmonary disease

Objective Through summarizing the clinical advance of bronchoscopic lung volume reduction （BLVR）in treating chronic obstructive pulmonary disease （COPD）,to provide more choices for the clinical treatment and research idea of COPD. Methods The related references in recent 20 years at home and abroad were collected, summarized and analyzed. Results BLVR was an minimally invasive technique with bronchoscopic to achieve lung volume reduction, which was no need thoracotomy according to the lung volume reduction surgery （I.VRS） principle. The commonly used methods were bronchus blocking method and bronchial fenestration. Its purpose was to obtain LVRS benefits, and reduce the surgical trauma, risk and long-term rehabilitation process. Conclusions BLVR was a new treatment method with no need thoraeotomy and small surgical trauma. In clinic, it reduced greatly the potential mortality and morbidity, and showed great clinical application prospect. But due to the lack of large scale randomized controlled clinical trials, some methods were still in the animal experiment stage and lack of clinical research, so BLVR was still in its infancy.