| 诱导多功能干细胞源性肝细胞治疗肝功能衰竭的研究进展 |
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| 引用本文： | 肖磊,李军根,刘运来. 诱导多功能干细胞源性肝细胞治疗肝功能衰竭的研究进展[J]. 国际生物医学工程杂志, 2014, 37(1): 49-52 |
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| 作者姓名： | 肖磊 李军根 刘运来 |
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| 作者单位： | 肖磊 (第三军医大学学员旅四营,重庆,400038)； 李军根 (第三军医大学学员旅四营,重庆,400038)； 刘运来 (第三军医大学组胚教研室)； |
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| 基金项目： | 国家973项目(项目编号：2010CB529400) |
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| 摘 要： | 肝细胞移植治疗多种原因造成的肝功能衰竭,在临床上已取得较好的疗效.诱导多功能干细胞（iPS）及其定向分化技术的进步,为获得大量、安全及具有生物学功能活性的肝细胞移植所需的种子细胞提供了一种新的方法.对iPS定向分化成肝细胞并应用于肝细胞移植治疗肝功能衰竭的研究进展进行综述.
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| 关 键 词： | 诱导多功能干细胞 胚胎干细胞 肝功能衰竭 肝细胞移植 |
Progress of treating hepatic failure with induced pluripotent stem cell-derived hepatocytes |
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| Xiao Lei,Li Jungen,Liu Yunlai. Progress of treating hepatic failure with induced pluripotent stem cell-derived hepatocytes[J]. International Journal of Biomedical Engineering, 2014, 37(1): 49-52 |
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| Authors: | Xiao Lei Li Jungen Liu Yunlai |
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| Affiliation: | 1.Fourth Battalion Student Brigade, Third Military Medical University, Chongqing 400038,China;) |
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| Abstract: | Hepatocyte transplantation is effective in the treatment of liver failure caused by a variety of factors.In pace with the progress of the study of induced pluripotent stem cells and its differentiation technology,a new method has arisen to obtain a great number of safe hepatocytes with biological function,which are suitable for seed cells of hepatocyte transplantation.In this article,we review the latest research progress about induced pluripotent stem cell-derived hepatocytes being transplanted to treat liver failure. |
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| Keywords: | Induced pluripotent stem cells Embryonic stem cells Hepatic failure Hepatocyte transplantation |
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