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基于荧光分子断层成像的多模成像系统研究进展
引用本文:周源,刘飞,阮秋琦,白净.基于荧光分子断层成像的多模成像系统研究进展[J].国际生物医学工程杂志,2014,37(1):43-48.
作者姓名:周源  刘飞  阮秋琦  白净
作者单位:周源 (100044,北京交通大学计算机与信息技术学院生物医学工程系); 刘飞 (清华大学医学院生物医学工程系, 北京,100084); 阮秋琦 (100044,北京交通大学信息科学研究所); 白净 (清华大学医学院生物医学工程系, 北京,100084);
基金项目:国家973计划资助项目(项目编号:2011CB707701),国家自然科学基金资助项目(项目编号:81227901,81071191,81271617)
摘    要:基于荧光分子断层成像(FMT)的多模成像系统已广泛应用于动物实验研究,它将现有的其他成像模态与FMT系统相融合,实现同时对被测生物解剖学结构、生理学功能和分子或细胞水平生物学活动的在体成像.首先介绍了单模FMT系统的发展历史和现状,并介绍了国内外基于FMT的多模系统的研究进展,着重介绍了文献报道的典型的FMT/CT、FMT/MRI和FMT/放射性核素成像系统的系统组成、工作原理、性能特点及实验应用.对基于FMT的多模成像系统的发展进行了展望.

关 键 词:荧光分子断层成像  多模成像系统  荧光分子断层成像  CT  荧光分子断层成像  MRI  荧光分子断层成像  放射性核素成像

Research progress in multi-modality imaging system based on fluorescence molecular tomography
Zhou Yuan,Liu Fei Ruan Qiuqi Bai Jing.Research progress in multi-modality imaging system based on fluorescence molecular tomography[J].International Journal of Biomedical Engineering,2014,37(1):43-48.
Authors:Zhou Yuan  Liu Fei Ruan Qiuqi Bai Jing
Institution:1.Department of Biomedical Engineering, School of Computer and Information Technology, Beijing Jiaotong University, Beijing 100044, China;)
Abstract:Multi-modality imaging system based on fluorescence molecular tomography (FMT) has been widely used in animal studies.It combines FMT with other imaging modalities,which realizes the imaging of anatomical structure,physiological function and biological activities on molecular or cellular levels of small animal in vivo at the same time.This review gives an introduction to the history and current research status of singlemodality FMT system,introduces the developments of multi-modality system based on FMT,especially the system setup,working principle,performance and application of FMT/CT,FMT/MRI and FMT/radionuclide imaging.The prospects of multi-modality imaging system based on FMT are discussed.
Keywords:Fluorescence molecular tomography  Multi-modality imaging system  FMT/CT  FMT/MRI  FMT/Radionuclide imaging
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