| JunceellinA水解产物的制备及其对肺癌A—549细胞的活性 |
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| 引用本文： | 林永成,金涛.JunceellinA水解产物的制备及其对肺癌A—549细胞的活性[J].中国海洋药物,1995,14(3):1-4. |
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| 作者姓名： | 林永成 金涛 |
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| 作者单位： | 中山大学化学系，中山大学化学系，广州医学院 广州 510275，广州 510275 |
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| 基金项目： | 国家教委博士点专项科研基金资助项目 |
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| 摘 要： | 从南海鳞灯芯珊瑚Ｊｕｎｃｅｌｌａｓｑｕａｍａｔａ分离出的ＪｕｎｃｅｅｌｌｉｎＡ（ＪＡ）分界用Ｋ２ＣＯ３和２ｍｏｌ／ＬＨＣｌ水解得到二羟基产物（ＪＡ）和四羟基产物（ＪＡ２），初步药理试验显示，ＪＡ１和ＪＡ２浓度在３０～５０μｇ／ｍＬ，具有抑制肺癌Ａ－５４９细胞生长的活性，ＪＡ２的效应比ＪＡ１强，ＪＡ２对正常人细胞的生长无影响。
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| 关 键 词： | JunceellinA 水解产物 肺肿瘤 A－549细胞 |
THE HYDROLYTIC PRODUCTS OF JUNCEELLIN A FROM JUNCEELLA SQUAMATA AND THEIR ACTIVITIES TO INHIBIT THE LUNG CANCER A-549 CELLS |
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| Lin Yongcheng,Jin Tao,Long Kanghou,et al..THE HYDROLYTIC PRODUCTS OF JUNCEELLIN A FROM JUNCEELLA SQUAMATA AND THEIR ACTIVITIES TO INHIBIT THE LUNG CANCER A-549 CELLS[J].Chinese Journal of Marine Drugs,1995,14(3):1-4. |
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| Authors: | Lin Yongcheng Jin Tao Long Kanghou |
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| Abstract: | Junceellin A (JA) from Junceella squamata was hydrolyzed in K2CO3 and 2 mol/L MCI and gave dihydroxy product (JA1),and tetrahydroxy product (JA2) respectively. The preliminary bioassay showed that JA1 and JA2 in 30~50 ug/mL had activities to inhibit the growth of lung cancer A-549 ceils. The effect of JAi was stronger than that of JA1. JA2 didn't affect the growth of human normal cells (HF). |
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| Keywords: | Junceellin A hydrolytic product anti-lung-cancer activity |
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