| 慢性肝病患者血清TNF—α、IL—8和血浆选择素水平的检测及其意义 |
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| 引用本文： | 罗清逢,高孝慈,龙尧,徐军发,郑兴武. 慢性肝病患者血清TNF—α、IL—8和血浆选择素水平的检测及其意义[J]. 临床内科杂志, 2001, 18(2): 117-119 |
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| 作者姓名： | 罗清逢 高孝慈 龙尧 徐军发 郑兴武 |
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| 作者单位： | 广东医学院附属医院感染内科 |
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| 摘 要： | 目的：探讨TNF－α、IL－8和P-selectin与慢性肝病的关系。方法应用双抗体夹心酶联免疫吸附法（ELISA）测定124例慢性肝病患者血清TNF－α、IL－8和P－selectin的水平。结果：慢性肝病患者血清TNF－α、IL－8和P－selectin水平均明显高于对照组（P值均＜0．001,P－selectin组P＜0．01）。结论TNF－α、IL－8和P－selctin可能与慢性肝病免疫病理损伤过程。检测血清TNF－α、IL－8和P－selectin水平对判断患者病情和预后有临床实用价值。
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| 关 键 词： | 病毒性肝炎 TNF－α 白细胞介素－8 血浆选择素 慢性肝病 |
| 文章编号： | 1001-9057(2001)02-0117-03 |
| 修稿时间： | 2000-01-20 |
Measurement andsignificance of serum TNF-a, IL-8 and plasma selectin levels in patients with chronichepatic diseases. |
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| LUO Qingfeng,GAO Xiaoci,LONG Rao,et al.. Measurement andsignificance of serum TNF-a, IL-8 and plasma selectin levels in patients with chronichepatic diseases.[J]. Journal of Clinical Internal Medicine, 2001, 18(2): 117-119 |
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| Authors: | LUO Qingfeng GAO Xiaoci LONG Rao et al. |
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| Affiliation: | LUO Qingfeng,GAO Xiaoci,LONG Rao,et al.Department of Infectious Diseases,Affiliated Hospital of Guangdong Medical College,Zhanjiang 524001,China |
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| Abstract: | Objective To investigate the relationship between TNF-a, IL-8, P-selectin and chronic hepatic diseases. Methods The serum TNF-α, IL-8 and plasma selectin levels in 124 patients were measured by ELISA. Results The TNF-α, IL-8 and P-selectin levels are significantly higher than normal controls( P＜0.001,P＜0.01). Conclusion The measurements of serum TNF-α, IL-8 and P-selectin levels have clinical value for judgement patients condition and prognosis. |
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