抑郁症首次发病维吾尔族、汉族患者血清白介素-2、6及其可溶性受体水平的对照研究

目的:探讨抑郁症首次发病的维吾尔族(维族)、汉族患者血清白介素(IL)-2、IL-6及其可溶性受体(sIL-2R、sIL-6R)水平的变化。方法:对117例首次发病的抑郁症患者(抑郁症组,维族亚组57例,汉族亚组60例)给予文拉法辛治疗4周。治疗前后采用汉密尔顿抑郁量表(HAMD)-17项评定病情,采用酶联免疫吸附法(ELISA)检测血清IL-2、IL-6及sIL-2R、sIL-6R水平;并与性别、年龄相匹配的正常对照组(维族、汉族各55例)比较。结果:抑郁症维族及汉族亚组HAMD评分治疗后较治疗前显著下降(P均0.01),两亚组间差异无统计学意义。抑郁症组治疗前血清IL-2、IL-6及sIL-2R、sIL-6R水平明显高于正常对照组(P均0.01),且IL-2、sIL-6R水平在维族与汉族亚组间差异有统计学意义(P均0.01);治疗后血清IL-2、IL-6及sIL-2R、sIL-6R水平较治疗前明显下降(P均0.01)。结论:维族和汉族抑郁症患者均有免疫失调;文拉法辛治疗能改善抑郁症病情及免疫失调。

Control study of levels of serum interleukin-2,6 and its soluble receptor in Uygur and Han patients with first onset depression

Objective： To explore the changes of levels of serum interleukin （IL）-2,IL-6 and their soluble receptors （sIL-2R,sIL-6R） in Uygur and Han patients with first onset depression.Method：One hundred and seventeen first onset depressive patients （depression group,57 cases in the Uygur subgroup and 60 cases in the Han subgroup） were assessed by Hamilton depression rating scale-17 items （HAMD）.The levels of serum IL-2,IL-6 and sIL-2R,sIL-6R were detected by Enzyme-linked immunosorbent assay （ELISA）.The results were compared with the gender,age-matched normal control group （55 Uygurs and 55 Hans）.Results：After treatment,the HAMD score was significantly decreased than before treatment in depression group （P＜0.01）;but the difference between the Uygur and the Han subgroups was not notable. Before treatment,the levels of serum IL-2,IL-6 and sIL-2R,sIL-6R in depression group were significantly higher than those in normal control group （all P＜0.01）;and the levels of serum IL-2,sIL-6R between the Uygur and the Han subgroups had significant difference （all P＜0.01）. After treatment,the levels of serum IL-2,IL-6 and sIL-2R,sIL-6R were decreased significantly（all P＜0.01）.Conclusion：The immunity dysregulation exists in both Han and Uygur depressive patients. Venlafaxine can improve the depressive condition and immunity dysregulation.