| 不同醉酒度浓香型白酒对小鼠酒精性肝损伤的影响 |
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| 引用本文： | 彭彦卿,张梦妍,党好,许欣,齐亚娜,李春艳,饶家权,马斌,杜礼泉.不同醉酒度浓香型白酒对小鼠酒精性肝损伤的影响[J].现代预防医学,2011,38(5):847-849. |
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| 作者姓名： | 彭彦卿 张梦妍 党好 许欣 齐亚娜 李春艳 饶家权 马斌 杜礼泉 |
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| 作者单位： | 1. 四川大学公共卫生学院,成都,610041
2. 四川省绵阳市丰谷酒业有限责任公司 |
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| 摘 要： | 目的]研究不同醉酒度浓香型白酒对小鼠肝损伤的影响。方法]以48.0%乙醇溶液为对照,以一次性及连续4周的方式分别经口给予BALB/c小鼠两种不同醉酒度浓香型白酒,测定血中谷丙转氨酶(ALT)、谷草转氨酶(AST)、甘油三酯(TG),肝中超氧化物歧化酶(SOD)、还原性谷胱甘肽(GSH)、丙二醛(MDA)含量,并进行病理组织学检查。结果]连续灌胃4周后,与醉酒度高的酒样组相比,低醉酒度组小鼠TG和MDA含量低(P﹤0.05);GSH含量高(P﹤0.01);肝组织脂肪变性、炎症及纤维化无统计学意义(P﹥0.05);一次性灌胃后各指标均未出现明显差异。结论]低醉酒度浓香型白酒对小鼠酒精性肝损伤的程度低于高醉酒度浓香型白酒。
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| 关 键 词： | 醉酒度 肝损伤 BALB/c小鼠 |
EFFECTS OF THE MICE' DEGREE OF DRUNKENNESS ON LIVER DAMAGE |
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| PENG Yan-qing,ZHANG Meng-yan,DANG Hao,et al..EFFECTS OF THE MICE' DEGREE OF DRUNKENNESS ON LIVER DAMAGE[J].Modern Preventive Medicine,2011,38(5):847-849. |
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| Authors: | PENG Yan-qing ZHANG Meng-yan DANG Hao |
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| Institution: | PENG Yan-qing,ZHANG Meng-yan,DANG Hao,et al.(West China School of Public Health,Sichuan University,Chengdu 610041,China) |
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| Abstract: | Objective]To investigate the effects of Luzhou-flavor liquor's degree of drunkenness on liver damage in mice.Methods]The control group was administered intragastrically 48.0% ethanol solution and the others administered two different varieties of Luzhou-flavor liquor with once and continued 4 weeks ways.When the mice were sacrificed,determined the contents of ALT,AST,TG in blood and SOD,GSH,MDA in liver.Meanwhile,took an inspection of pathological histology on liver.Results]There was statistically differ... |
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| Keywords: | Degree of drunkenness Liver damage BALB/c mice |
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