| 抗结核药物引起药物性肝损害的临床特点分析 |
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| 引用本文： | 安慧茹,吴雪琼,王仲元,徐静,郑少华,王坤.抗结核药物引起药物性肝损害的临床特点分析[J].四川医学,2011,32(5):633-636. |
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| 作者姓名： | 安慧茹 吴雪琼 王仲元 徐静 郑少华 王坤 |
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| 作者单位： | 解放军第309医院全军结核病研究所,北京,100091 |
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| 基金项目： | 北京市科技计划研发攻关类科研基金资助项目 |
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| 摘 要： | 目的探讨抗结核药物性肝损害的临床特点及易感因素。方法回顾性分析2457例结核病患者发生抗结核药物性肝损害的临床特点及其相关因素。结果 2457例初治结核患者中,267例（10.9%）发生抗结核药物性肝损害,其中女性抗结核药物性肝损害的发生率（13.6%,148/1085）显著高于男性（8.7%,119/1372,P〈0.05）;未接受保肝药物治疗患者的抗结核药物性肝损害的发生率（13.8%,80/581）显著高于接受保肝药物治疗者（10.0%,187/1876,P〈0.05）;接受含HRZ方案的患者抗结核药物性肝损害的发生率（13.2%,139/1050）显著高于接受含HR方案治疗者（9.1%,128/1407,P〈0.05）。结论女性是抗结核药物性肝损害的易患因素;合理使用保肝药物有可能减低易患患者的抗结核药物性肝损害的发生率;HRZ联用较HR联用致抗结核药物性肝损害的发生率高。
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| 关 键 词： | 肝损害 抗结核药物 临床特点 易感因素 |
The clinical characteristic of antituberculosis drug-induced liver injury and its relationship with gene polymorphism of drug metabolizing enzymes |
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| AN Hui-ru,WU Xue-qiong,WANG Zhong-yuan,et al..The clinical characteristic of antituberculosis drug-induced liver injury and its relationship with gene polymorphism of drug metabolizing enzymes[J].Sichuan Medical Journal,2011,32(5):633-636. |
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| Authors: | AN Hui-ru WU Xue-qiong WANG Zhong-yuan |
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| Institution: | AN Hui-ru,WU Xue-qiong,WANG Zhong-yuan,et al.Department of Tuberculosis,The 309th Hospital of PLA,Beijing 100091,China |
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| Abstract: | Objective To study the clinical characteristics and predisposing factor of antituberculosis drug-induced liver injury.Methods The clinical characteristics and correlative factors of 2457 cases with tuberculosis(TB) who had been inpatiented for initial treatment between 2005 and 2009 were retrospectively analyzed.Results Of the 2457 TB patients who received initial treatment,267(10.9%) patients had antituberculosis drug-induced liver injury;13.6%(148/1085) female patients had antituberculosis drug-induced li... |
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| Keywords: | liver injury anti-tuberculosis drugs clinical characteristics predisposing factor |
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