| 血必净注射液对大鼠急性肺损伤的作用 |
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| 引用本文： | 王光权,王龙. 血必净注射液对大鼠急性肺损伤的作用[J]. 现代预防医学, 2011, 38(5): 996-998,1001 |
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| 作者姓名： | 王光权 王龙 |
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| 作者单位： | 海南省琼海市人民医院加强治疗科,琼海,57140 |
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| 摘 要： | [目的]探讨血必净注射液对大鼠急性肺损伤的干预作用及其机制。[方法]成年雄性Wistar大鼠36只随机分为3组:假手术组(C)、缺血再灌注组(I/R)、血必净组(XBJ),每组12只。通过阻断肠系膜上动脉的方法造成肠缺血再灌注模型。分别观察各组动物肺组织病理变化;测定肺组织丙二醛(MDA)、髓过氧化物酶(MPO)活性;以及肺组织TNF-α、IL-1β、IL-6的mRNA水平。[结果]缺血再灌注组肺泡壁明显增厚、间质内有大量多型核细胞浸润,肺组织MDA含量、MPO活性显著升高,TNF-α、IL-1β、IL-6mRNA水平明显高于假手术组。血必净组上述指标则低于缺血再灌注组。[结论]血必净注射液能有效的降低小肠缺血-再灌注致大鼠急性肺损伤,其作用机制可能和下调TNF-α、IL-1β、IL-6等表达有关。
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| 关 键 词： | 急性肺损伤 缺血-再灌注 细胞因子 血必净 |
THE EFFECTS OF XUEBIJING INJECTION ON ACUTE LUNG INJURY IN RATS |
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| WANG Guang-quan,WANG Long. THE EFFECTS OF XUEBIJING INJECTION ON ACUTE LUNG INJURY IN RATS[J]. Modern Preventive Medicine, 2011, 38(5): 996-998,1001 |
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| Authors: | WANG Guang-quan WANG Long |
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| Affiliation: | WANG Guang-quan,WANG Long.(Department of Intensive Therapy,People's Hospital of Qionghai City in Hainan Province,Qionghai 571400,China) |
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| Abstract: | [Objective]To discuss the effects on acute lung injury induced by intestinal ischemia-reperfusion of Xuebijing injection and its potential mechanism.[Methods]36 adult male Wistar rats were randomly divided into 3 groups:Sham operation control group(C),ischemia-reperfusion group(I/R)and I/R+Xuebijing injection group(XBJ),12 animals in each group.Acute lung injury rat model was established by intestinal ischemia-reperfusion.The pathological change of lung tissue,the level of malondialdehyde(MDA),activity of m... |
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| Keywords: | Acute lung injury Ischemia-reperfusion Cytokine Xuebijing injection |
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