| 晚期日本血吸虫病合并HBV感染的临床和病理研究 |
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| 引用本文： | 李祖进,顾寄真,宋光放,刘绍春,杨业翔,殷修云.晚期日本血吸虫病合并HBV感染的临床和病理研究[J].华中科技大学学报(医学版),1988(5). |
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| 作者姓名： | 李祖进 顾寄真 宋光放 刘绍春 杨业翔 殷修云 |
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| 作者单位： | 同济医科大学附属同济医院传染病学教研室
(李祖进，顾寄真)，同济医科大学基础医学部病理解剖学教研室
(宋光放，刘绍春)，湖北省江陵县血吸虫病防治站
(杨业翔)，湖北省汉阳县血吸虫病防治站(殷修云) |
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| 摘 要： | 采用双桥PAP法检测155例晚期血吸虫病(晚血)患者肝内HBsAg和HBcAg,结果88例(56.8％)HBsAg或(和)HBcAg阳性,肝内HBAg阳性组的肝脏病理变化和临床表现显著比阴性组严重,晚血患者发生的门脉性肝硬化大多数与合并HBV感染有关。提示合并HBV感染可以明显加重晚血患者的临床表现和肝脏病变,甚至是晚血患者发生门脉性肝硬化的主要原因。
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| 关 键 词： | 晚期血吸虫病 HBsAg HBcAg HBv 门脉性肝硬化 |
A Clinico-pathological Study of Patients with Advanced Schistosomiasis Japonica Complicated by HBV Infection |
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| Li Zujin,Gu Jizhen,Song Guangfang,Liu Shaochun,Yang Yexiang,Yin Yiuyun.A Clinico-pathological Study of Patients with Advanced Schistosomiasis Japonica Complicated by HBV Infection[J].Journal of Huazhong University of Science and Technology(Health Sciences),1988(5). |
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| Authors: | Li Zujin Gu Jizhen Song Guangfang Liu Shaochun Yang Yexiang Yin Yiuyun |
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| Institution: | Li Zujin,Gu Jizhen,Song Guangfang,Liu Shaochun,Yang Yexiang,Yin Yiuyun Department of Infectious Diseases,Tongji Hospital,Tongji Medical University,WuhanDepartment of Pathology,Tongji Medical University,WuhanJiangling Station of Antischistosomiasis,Jiangling County,Hubei ProvinceHanyang Station of Antischistosomiasis,Hanyang County,Hubei Province |
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| Abstract: | HBsAg and HBcAg in the wedge biopsies of livers from 155 patients with advaced schistosomiasis japonica were detected with double bridge perioxidase-anti-perioxidase (PAP) method. 88 of 155 (56.8%) cases were found to be HBsAg or/and HBcAg positive in liver. The patients with HBAg positive in liver underwent significantly more severe pathological changes of liver parenchema and clinical manifestations than those without HBAg in liver. The portal cirrhosis occurring in the patients with advanced schistosomiasis was mostly related to the complication of HBV infection and bore no relation to the density of schistosoma ova in liver. Our experimental results indicate that superimposed HBV infection can greatly aggravate the pathological changes of liver, clinical manifestations and abnormality of liver function in patients with advanced sehistosomiasis, and that it may even be the major cause of the portal cirrhosis developing in patients with advanced schistosomiasis. |
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| Keywords: | advanced schistosomiasis HBsAg HBcAg HBV portal cirrhosis |
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