| 山药多糖对2型糖尿病大鼠肾病的预防作用研究 |
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| 引用本文： | 杨宏莉,张宏馨,王燕,李兰会,崔杰,王桂珍,曲静.山药多糖对2型糖尿病大鼠肾病的预防作用研究[J].中国药房,2010(15):1345-1347. |
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| 作者姓名： | 杨宏莉 张宏馨 王燕 李兰会 崔杰 王桂珍 曲静 |
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| 作者单位： | 河北大学医学部;河北农业大学动物科技学院;河北景县人民医院;北京市第三社会福利院;河北省荣军医院; |
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| 基金项目： | 河北省科技技术项目(08206416D); 河北中医药局科研计划课题(2007006) |
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| 摘 要： | 目的:研究山药多糖对2型糖尿病大鼠肾病的预防作用。方法:采用链脲佐菌素(STZ)腹腔注射的方法复制2型糖尿病大鼠模型,用山药多糖干预治疗4周,检测血清胰岛素及胰高血糖素、肾组织胰岛素受体(InsR)、胰岛素受体底物-(lIRS-l)、磷酯酰肌醇3激酶(PI-3K)的表达水平。结果:山药多糖可显著升高模型大鼠胰岛素水平(P<0.01),显著降低胰高血糖素水平(P<0.01),显著升高模型大鼠肾组织InsR、IRS-1、PI-3K表达水平(P<0.05)。结论:山药多糖对2型糖尿病大鼠的治疗作用机制可能与提高糖尿病大鼠肾组织中InsR、IRS-1、PI-3K水平,增加组织对胰岛素的敏感性,改善胰岛素信号传导有关。
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| 关 键 词： | 山药多糖 2型糖尿病 胰岛素 胰高血糖素 胰岛素受体 胰岛素受体底物-1 磷酯酰肌醇3激酶 |
Prevention Effects of Polysaccharides from Dioscorea opposita on Kidney Disease in Rats with Type 2 Diabetes Mellitus |
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| YANG Hong-li,ZHANG Hong-xin,WANG Yan LI Lan-hu CUI Jie WANG Gui-zhen QU Jing.Prevention Effects of Polysaccharides from Dioscorea opposita on Kidney Disease in Rats with Type 2 Diabetes Mellitus[J].China Pharmacy,2010(15):1345-1347. |
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| Authors: | YANG Hong-li ZHANG Hong-xin WANG Yan LI Lan-hu CUI Jie WANG Gui-zhen QU Jing |
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| Institution: | YANG Hong-li,ZHANG Hong-xin,WANG Yan(Hebei University Medical Science Department,Baoding 071000,China) LI Lan-hu(iCollege of Animal Science,Agricultural University of Hebei,China) CUI Jie(Jingxian County People\'s Hospital of Hebei Province,Hengshui 053500,China) WANG Gui-zhen(Beijing Third Welfare House,Beijing 100089,China) QU Jing(Rongjun Hospital of Hebei Province,China) |
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| Abstract: | OBJECTIVE:To investigate prevention effects of polysaccharides from Dioscorea opposita on kidney disease in rats with type 2 diabetes mellitus. METHODS:Type 2 diabetic models were induced by injecting with streptozotocin(STZ). After 4 weeks of treatment,the expression of glucagon,serum insulin,InsR,IRS-1 and PI-3K in rats were determined. RESULTS:D. opposita can significantly increased the levels of serum insulin(P<0.01)and the expression of InsR,IRS-1 and PI-3K in model rats(P<0.05). It can decrease the le... |
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| Keywords: | Polysaccharides from Dioscorea opposita Type 2 diabetes mellitus Insulin Glucagon Insulin receptor Insulin receptor substrates-1 Phosphatidylinositol 3 kinase |
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