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Determination of Clarithromycin as a Contaminant on Surfaces by High-Performance Liquid Chromatography Using Electrochemical Detection |
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| Authors: | Rotsch Terry D. Spanton Meredith Cugier Phyllis Plasz Andrew C. |
| Affiliation: | (1) Analytical Research Department, Abbott Laboratories, North Chicago, Illinois, 60064;(2) Abbott Laboratories, Department 417, North Chicago, Illinois, 60064 |
| Abstract: | Microgram levels of clarithromycin residues on various surfaces are quantitated. After cleaning, any residual clarithromycin remaining is removed from the surface by a wet swab–dry swab technique. High-performance liquid chromatography with electrochemical detection is used for quantitation of the resulting solutions. Recoveries ranged from 93 to 118%. |
| Keywords: | clarithromycin cleaning validation high-performance liquid chromatography electrochemical detection residue on surfaces |
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